Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Rptor. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• The gene product of Rptor has been shown to bind to the gene products of Mtor. ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Rptor:
  • participates in the following biological processes:
    • cell growth
    • cellular response to amino acid stimulus
    • cellular response to nutrient levels
    • positive regulation of endothelial cell proliferation
    • positive regulation of protein serine/threonine kinase activity
    • positive regulation of TOR signaling cascade
    • positive regulation of transcription from RNA polymerase III promoter
    • regulation of cell size
    • regulation of phosphorylation
    • TOR signaling cascade
  • performs the following molecular functions:
    • 14-3-3 protein binding
    • protein complex binding
    • protein kinase binding
    • RNA polymerase III type 1 promoter DNA binding
    • RNA polymerase III type 2 promoter DNA binding
    • RNA polymerase III type 3 promoter DNA binding
    • TFIIIC-class transcription factor binding
  • is located in the following cellular components:
    • cytoplasm
    • dendrite
    • lysosome
    • neuronal cell body
    • TORC1 complex

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References

1. Takai H et al. (2010) Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes. Genes Dev, 24:2019-30. (PubMed:20801936)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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