Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Npl. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of October 28, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the N-acetylneuraminate lyase sub-family of (beta/alpha)(8)-barrel enzymes. N-acetylneuraminate lyases regulate cellular concentrations of N-acetyl-neuraminic acid (sialic acid) by mediating the reversible conversion of sialic acid into N-acetylmannosamine and pyruvate. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Npl
  • performs the following molecular functions:
    • N-acetylneuraminate lyase activity ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Npl:
  • participates in the following biological processes:
    • metabolic process
  • performs the following molecular functions:
    • N-acetylneuraminate lyase activity

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Summary text based on GO annotations supported by structural data

• Npl encodes a protein or proteins that contain the following InterPro domains: Aldolase-type TIM barrel, Dihydrodipicolinate synthetase-like, indicating that the gene product:
  • performs the following molecular functions:
    • catalytic activity
    • lyase activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Npl indicates that it:
  • participates in the following biological processes:
    • carbohydrate metabolic process
  • performs the following molecular functions:
    • lyase activity
  • is located in the following cellular components:
    • cytoplasm
• Annotations directly to for the gene Npl indicate that MGI curators have found no experimental data [literature] to support further annotation to these categories at this time.

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References

1. Bergfeld AK et al. (2012) Metabolism of vertebrate amino sugars with N-glycolyl groups: elucidating the intracellular fate of the non-human sialic acid N-glycolylneuraminic acid. J Biol Chem, 287:28865-81. (PubMed:22692205)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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