Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Adipor1. (This text reflects annotations as of Wednesday, January 23, 2013.)

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14. [provided by RefSeq, Jan 2012]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Adipor1
  • performs the following molecular functions:
    • identical protein binding ^[2]
    • receptor activity ^[2]
• The gene product of Adipor1 has been shown to bind to the gene products of Adipoq. ^{[1, 2]} Researchers have inferred, based on physical interactions, that the gene product of Adipor1
  • performs the following molecular functions:
    • protein heterodimerization activity ^[2]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Adipor1:
  • participates in the following biological processes:
    • adiponectin-mediated signaling pathway
    • fatty acid oxidation
    • hormone-mediated signaling pathway
    • leptin-mediated signaling pathway
    • negative regulation of cell growth
    • positive regulation of insulin receptor signaling pathway
    • positive regulation of JAK-STAT cascade
  • performs the following molecular functions:
    • hormone binding
    • protein kinase binding
  • is located in the following cellular components:
    • plasma membrane
    • plasma membrane part

---

Summary text based on GO annotations supported by structural data

• Adipor1 encodes a protein or proteins that contain the following InterPro domains: Hly-III-related, indicating that the gene product:
  • is located in the following cellular components:
    • integral to membrane

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Adipor1 indicates that it:
  • participates in the following biological processes:
    • fatty acid metabolic process
    • lipid metabolic process
  • is located in the following cellular components:
    • integral to membrane
    • membrane

---

References

1. Mao X et al. (2006) APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function. Nat Cell Biol, 8:516-23. (PubMed:16622416)
2. Yamauchi T et al. (2003) Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature, 423:762-9. (PubMed:12802337)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---