Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cul4b. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 9, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Cul4b
  • participates in the following biological processes:
    • positive regulation of protein catabolic process ^[1]
    • positive regulation of S phase of mitotic cell cycle ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Cul4b:
  • is located in the following cellular components:
    • Cul4B-RING ubiquitin ligase complex
    • nucleus
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Cul4b encodes a protein or proteins that contain the following InterPro domains: Cullin homology, Cullin protein, neddylation domain, Cullin repeat-like-containing domain, Cullin, conserved site, Cullin, N-terminal, Winged helix-turn-helix transcription repressor DNA-binding, indicating that the gene product:
  • participates in the following biological processes:
    • ubiquitin-dependent protein catabolic process
  • performs the following molecular functions:
    • ubiquitin protein ligase binding
  • is located in the following cellular components:
    • cullin-RING ubiquitin ligase complex

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Cul4b indicates that it:
  • participates in the following biological processes:
    • cell cycle
    • DNA repair
    • response to DNA damage stimulus

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References

1. Dooley S et al. (2008) Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated fibrogenesis and protects against liver damage. Gastroenterology, 135:642-59. (PubMed:18602923)
2. Miranda-Carboni GA et al. (2008) A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. Genes Dev, 22:3121-34. (PubMed:19056892)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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