Automated description from the Alliance of Genome Resources (Release 5.1.1)
Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and positive regulation of protein ubiquitination. Acts upstream of or within myotube differentiation and negative regulation of cellular protein metabolic process. Located in A band and I band. Part of Cul3-RING ubiquitin ligase complex. Is expressed in several structures, including diaphragm; genitourinary system; limb segment; musculature; and paraxial mesenchyme. Used to study nemaline myopathy 8. Human ortholog(s) of this gene implicated in nemaline myopathy 8. Orthologous to human KLHL40 (kelch like family member 40).