Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Trmu. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 9, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the trmU family. It encodes a mitochondria-specific tRNA-modifying enzyme that is required for the 2-thio modification of 5-taurinomethyl-2-thiouridine tRNA-Lys on the wobble position of the anticodon. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Trmu
  • is located in the following cellular components:
    • mitochondrion ^{[1, 2]}

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Summary text based on GO annotations supported by structural data

• Trmu encodes a protein or proteins that contain the following InterPro domains: Adenine nucleotide alpha hydrolase-like domains, Rossmann-like alpha/beta/alpha sandwich fold, tRNA-specific 2-thiouridylase, indicating that the gene product:
  • participates in the following biological processes:
    • tRNA processing
  • performs the following molecular functions:
    • sulfurtransferase activity
    • transferase activity
  • is located in the following cellular components:
    • cytoplasm

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Trmu indicates that it:
  • participates in the following biological processes:
    • tRNA processing
  • performs the following molecular functions:
    • ATP binding
    • nucleotide binding
    • RNA binding
    • transferase activity
    • tRNA binding
• Annotations directly to for the gene Trmu indicate that MGI curators have found no experimental data [literature] to support further annotation to these categories at this time.

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References

1. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)
2. Yan Q et al. (2004) Identification and characterization of mouse TRMU gene encoding the mitochondrial 5-methylaminomethyl-2-thiouridylate-methyltransferase. Biochim Biophys Acta, 1676:119-26. (PubMed:14746906)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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