Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Optn. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Optn
  • is located in the following cellular components:
    • perinuclear region of cytoplasm ^[1]
• The gene product of Optn has been shown to bind to the gene products of Pkd2. ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Optn
  • participates in the following biological processes:
    • cellular protein localization ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Optn:
  • participates in the following biological processes:
    • Golgi organization
    • Golgi ribbon formation
    • Golgi to plasma membrane protein transport
    • protein homooligomerization
    • protein targeting to Golgi
  • performs the following molecular functions:
    • identical protein binding
    • protein C-terminus binding
    • TFIIIA-class transcription factor binding
  • is located in the following cellular components:
    • cytoplasm
    • cytoplasmic membrane-bounded vesicle
    • Golgi apparatus
    • trans-Golgi network

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References

1. Rezaie T et al. (2005) Molecular cloning, genomic structure, and protein characterization of mouse optineurin. Genomics, 85:131-8. (PubMed:15607428)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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