Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Wwtr1. (This text reflects annotations as of Tuesday, May 21, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of March 7, 2007. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

This gene encodes a binding protein of the 14-3-3 family of proteins that regulate cell cycle progression, differentiation and apoptosis. The encoded protein is a transcriptional co-activator that binds to the PPXY motif present on transcription factors. The gene product contains a WW domain and, in the C-terminus, a conserved PDZ-binding motif. This gene is distinct from the gene encoding tafazzin. Both genes share the gene symbol Taz. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Wwtr1
  • participates in the following biological processes:
    • positive regulation of transcription from RNA polymerase II promoter ^[10]
    • regulation of transcription, DNA-dependent ^[10]
  • performs the following molecular functions:
    • protein homodimerization activity ^[9]
    • transcription coactivator activity ^[9]
  • is located in the following cellular components:
    • cytoplasm ^{[3, 6]}
    • nucleus ^{[2, 6, 8]}
    • transcription factor complex ^[10]
• The gene product of Wwtr1 has been shown to bind to the gene products of Crebbp, Nkx2-1, Pax3, Pparg, Yap1, Ywhab. ^{[1, 3, 5, 6, 8, 9, 10]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Wwtr1
  • participates in the following biological processes:
    • cilium morphogenesis ^[4]
    • glomerulus development ^[7]
    • osteoblast differentiation ^[3]
• Researchers have inferred, based on genetic interactions, that the gene product of Wwtr1
  • participates in the following biological processes:
    • negative regulation of fat cell differentiation based on interactions with Pparg ^[3]
    • negative regulation of transcription from RNA polymerase II promoter based on interactions with Pparg ^[3]
    • osteoblast differentiation based on interactions with Bmp2 ^[3]
    • positive regulation of transcription from RNA polymerase II promoter based on interactions with Nkx2-1, Pax3, Runx2 ^{[3, 8, 10]}
  • performs the following molecular functions:
    • transcription corepressor activity based on interactions with Pparg ^[3]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Wwtr1:
  • participates in the following biological processes:
    • hippo signaling cascade
    • negative regulation of canonical Wnt receptor signaling pathway
    • negative regulation of catenin import into nucleus
    • negative regulation of protein kinase activity
    • negative regulation of protein phosphorylation
    • positive regulation of cell proliferation
    • positive regulation of epithelial to mesenchymal transition
    • regulation of SMAD protein import into nucleus
    • stem cell division
  • performs the following molecular functions:
    • transcription coactivator activity
  • is located in the following cellular components:
    • cytoplasm
    • nucleus

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Wwtr1 indicates that it:
  • participates in the following biological processes:
    • transcription, DNA-dependent

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References

1. Azzolin L et al. (2012) Role of TAZ as mediator of Wnt signaling. Cell, 151:1443-56. (PubMed:23245942)
2. Di Palma T et al. (2009) TAZ is a coactivator for Pax8 and TTF-1, two transcription factors involved in thyroid differentiation. Exp Cell Res, 315:162-75. (PubMed:19010321)
3. Hong JH et al. (2005) TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science, 309:1074-8. (PubMed:16099986)
4. Hossain Z et al. (2007) Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1. Proc Natl Acad Sci U S A, 104:1631-6. (PubMed:17251353)
5. Jiang Y et al. (2010) A novel mechanism of cell growth regulation by Cell Cycle and Apoptosis Regulatory Protein (CARP)-1. J Mol Signal, 5:7. (PubMed:20594350)
6. Kanai F et al. (2000) TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins. EMBO J, 19:6778-91. (PubMed:11118213)
7. Makita R et al. (2008) Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ. Am J Physiol Renal Physiol, 294:F542-53. (PubMed:18172001)
8. Murakami M et al. (2006) Transcriptional activity of Pax3 is co-activated by TAZ. Biochem Biophys Res Commun, 339:533-9. (PubMed:16300735)
9. Murakami M et al. (2005) A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome. Proc Natl Acad Sci U S A, 102:18034-9. (PubMed:16332960)
10. Park KS et al. (2004) TAZ interacts with TTF-1 and regulates expression of surfactant protein-C. J Biol Chem, 279:17384-90. (PubMed:14970209)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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