Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables protein homodimerization activity; transcription coactivator activity; and transcription corepressor activity. Involved in heart process; positive regulation of protein localization to nucleus; and tissue homeostasis. Acts upstream of or within several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; kidney development; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; brain; branchial arch; genitourinary system; and heart. Used to study nephronophthisis. Orthologous to human WWTR1 (WW domain containing transcription regulator 1).