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Gene Ontology Classifications
Symbol
Name
ID
Wwtr1
WW domain containing transcription regulator 1
MGI:1917649

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Wwtr1. (This text reflects annotations as of Thursday, July 24, 2014.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of March 7, 2007. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq


This gene encodes a binding protein of the 14-3-3 family of proteins that regulate cell cycle progression, differentiation and apoptosis. The encoded protein is a transcriptional co-activator that binds to the PPXY motif present on transcription factors. The gene product contains a WW domain and, in the C-terminus, a conserved PDZ-binding motif. This gene is distinct from the gene encoding tafazzin. Both genes share the gene symbol Taz. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text for additional MGI annotations
References
  1. Azzolin L et al. (2012) Role of TAZ as mediator of Wnt signaling. Cell, 151:1443-56. (PubMed:23245942)
  2. Das A et al. (2013) Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation. Nat Cell Biol, 15:1035-44. (PubMed:23974041)
  3. Di Palma T et al. (2009) TAZ is a coactivator for Pax8 and TTF-1, two transcription factors involved in thyroid differentiation. Exp Cell Res, 315:162-75. (PubMed:19010321)
  4. Hong JH et al. (2005) TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science, 309:1074-8. (PubMed:16099986)
  5. Hossain Z et al. (2007) Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1. Proc Natl Acad Sci U S A, 104:1631-6. (PubMed:17251353)
  6. Jiang Y et al. (2010) A novel mechanism of cell growth regulation by Cell Cycle and Apoptosis Regulatory Protein (CARP)-1. J Mol Signal, 5:7. (PubMed:20594350)
  7. Kanai F et al. (2000) TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins. EMBO J, 19:6778-91. (PubMed:11118213)
  8. Makita R et al. (2008) Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ. Am J Physiol Renal Physiol, 294:F542-53. (PubMed:18172001)
  9. Murakami M et al. (2006) Transcriptional activity of Pax3 is co-activated by TAZ. Biochem Biophys Res Commun, 339:533-9. (PubMed:16300735)
  10. Murakami M et al. (2005) A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome. Proc Natl Acad Sci U S A, 102:18034-9. (PubMed:16332960)
  11. Park KS et al. (2004) TAZ interacts with TTF-1 and regulates expression of surfactant protein-C. J Biol Chem, 279:17384-90. (PubMed:14970209)
  12. Remue E et al. (2010) TAZ interacts with zonula occludens-1 and -2 proteins in a PDZ-1 dependent manner. FEBS Lett, 584:4175-80. (PubMed:20850437)



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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory