Automated description from the Alliance of Genome Resources
Predicted to have chloride channel inhibitor activity; potassium channel inhibitor activity; and protein serine/threonine kinase activity. Involved in several processes, including chloride transport; negative regulation of pancreatic juice secretion; and protein localization. Localizes to the bicellular tight junction and cytoplasm. Used to study Gitelman syndrome. Human ortholog(s) of this gene implicated in hypertension and pseudohypoaldosteronism. Is expressed in several structures, including alimentary system; metanephros; metatarsal bone; sensory organ; and turbinate bone primordium. Orthologous to human WNK4 (WNK lysine deficient protein kinase 4).