Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Zdhhc15. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 9, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the DHHC palmitoyltransferase family. Mutations in this gene are associated with mental retardatio X-linked type 91 (MRX91). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Zdhhc15
  • participates in the following biological processes:
    • establishment of protein localization ^[1]
    • protein palmitoylation ^[1]
  • performs the following molecular functions:
    • palmitoyltransferase activity ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Zdhhc15
  • participates in the following biological processes:
    • synaptic vesicle maturation ^[1]
• Researchers have inferred, based on genetic interactions, that the gene product of Zdhhc15
  • participates in the following biological processes:
    • synaptic vesicle maturation based on interactions with Dlg4 ^[1]

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Summary text based on GO annotations supported by structural data

• Zdhhc15 encodes a protein or proteins that contain the following InterPro domains: Zinc finger, DHHC-type, palmitoyltransferase, indicating that the gene product:
  • performs the following molecular functions:
    • zinc ion binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Zdhhc15 indicates that it:
  • performs the following molecular functions:
    • metal ion binding
    • transferase activity
    • transferase activity, transferring acyl groups
  • is located in the following cellular components:
    • integral to membrane
    • membrane
• Annotations directly to for the gene Zdhhc15 indicate that MGI curators have found no experimental data [literature] to support further annotation to this category at this time.

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References

1. Fukata M et al. (2004) Identification of PSD-95 Palmitoylating Enzymes. Neuron, 44:987-96. (PubMed:15603741)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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