Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Gnpda2. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 9, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an allosteric enzyme that catalyzes the reversible reaction converting D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium. Variations of this gene have been reported to be associated with influencing body mass index and susceptibility to obesity. A pseudogene of this gene is located on chromosome 9. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Gnpda2:
  • participates in the following biological processes:
    • metabolic process
  • performs the following molecular functions:
    • glucosamine-6-phosphate deaminase activity

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Summary text based on GO annotations supported by structural data

• Gnpda2 encodes a protein or proteins that contain the following InterPro domains: Glucosamine-6-phosphate isomerase, Glucosamine-6-phosphate isomerase, conserved site, Glucosamine/galactosamine-6-phosphate isomerase, indicating that the gene product:
  • participates in the following biological processes:
    • carbohydrate metabolic process
    • N-acetylglucosamine metabolic process

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Gnpda2 indicates that it:
  • participates in the following biological processes:
    • carbohydrate metabolic process
  • performs the following molecular functions:
    • hydrolase activity
  • is located in the following cellular components:
    • cytoplasm
• Annotations directly to for the gene Gnpda2 indicate that MGI curators have found no experimental data [literature] to support further annotation to this category at this time.

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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