Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Dcxr. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 9, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene acts as a homotetramer to catalyze diacetyl reductase and L-xylulose reductase reactions. The encoded protein may play a role in the uronate cycle of glucose metabolism and in the cellular osmoregulation in the proximal renal tubules. Defects in this gene are a cause of pentosuria. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Dcxr
  • participates in the following biological processes:
    • glucose metabolic process ^[1]
    • NADP metabolic process ^[1]
    • oxidation-reduction process ^[1]
    • protein homotetramerization ^[1]
    • xylulose metabolic process ^[1]
  • performs the following molecular functions:
    • L-xylulose reductase (NADP+) activity ^[1]
    • oxidoreductase activity, acting on CH-OH group of donors ^[1]
  • is located in the following cellular components:
    • brush border ^[1]
    • microvillus ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Dcxr:
  • participates in the following biological processes:
    • glucose metabolic process
    • oxidation-reduction process
    • protein homotetramerization
    • xylulose metabolic process
  • performs the following molecular functions:
    • L-xylulose reductase (NADP+) activity
    • oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

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Summary text based on GO annotations supported by structural data

• Dcxr encodes a protein or proteins that contain the following InterPro domains: Glucose/ribitol dehydrogenase, NAD(P)-binding domain, Short-chain dehydrogenase/reductase SDR, Short-chain dehydrogenase/reductase, conserved site, indicating that the gene product:
  • participates in the following biological processes:
    • metabolic process
    • oxidation-reduction process
  • performs the following molecular functions:
    • nucleotide binding
    • oxidoreductase activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Dcxr indicates that it:
  • participates in the following biological processes:
    • carbohydrate metabolic process
    • D-xylose metabolic process
    • oxidation-reduction process
  • performs the following molecular functions:
    • oxidoreductase activity
  • is located in the following cellular components:
    • membrane
    • plasma membrane

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References

1. Nakagawa J et al. (2002) Molecular characterization of Mammalian dicarbonyl/l-xylulose reductase and its localization in kidney. J Biol Chem, 277:17883-91. (PubMed:11882650)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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