Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cdt1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of the protein. [provided by RefSeq, Mar 2011]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Cdt1
  • participates in the following biological processes:
    • DNA replication checkpoint ^[4]
    • regulation of DNA-dependent DNA replication initiation ^[4]
    • regulation of S phase of mitotic cell cycle ^[1]
  • performs the following molecular functions:
    • DNA binding ^[4]
  • is located in the following cellular components:
    • nucleus ^[3]
• The gene product of Cdt1 has been shown to bind to the gene products of Gmnn, Mcm6. ^{[2, 4]}

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Cdt1:
  • participates in the following biological processes:
    • DNA replication checkpoint
    • regulation of DNA-dependent DNA replication initiation
  • is located in the following cellular components:
    • nucleus

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Cdt1 indicates that it:
  • participates in the following biological processes:
    • cell cycle
    • DNA replication

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References

1. Arentson E et al. (2002) Oncogenic potential of the DNA replication licensing protein CDT1. Oncogene, 21:1150-8. (PubMed:11850834)
2. Lee C et al. (2004) Structural basis for inhibition of the replication licensing factor Cdt1 by geminin. Nature, 430:913-7. (PubMed:15286659)
3. Sugimoto N et al. (2004) Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding. J Biol Chem, 279:19691-7. (PubMed:14993212)
4. Yanagi K et al. (2002) Mouse geminin inhibits not only Cdt1-MCM6 interactions but also a novel intrinsic Cdt1 DNA binding activity. J Biol Chem, 277:40871-80. (PubMed:12192004)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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