Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Aspn. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

This gene encodes a member of the small leucine-rich proteoglycan family. The encoded protein is an extracellular matrix protein that modulates the transforming growth factor-beta signaling pathway, regulating cartilage matrix gene expression and cartilage formation. The protein plays a role in the pathology of osteoarthritis. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Aspn
  • participates in the following biological processes:
    • negative regulation of tooth mineralization ^[3]
    • negative regulation of transforming growth factor beta receptor signaling pathway ^[2]
  • is located in the following cellular components:
    • proteinaceous extracellular matrix ^[1]
• The gene product of Aspn has been shown to bind to the gene products of Bmp2. ^{[2, 3]}

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Aspn:
  • participates in the following biological processes:
    • bone mineralization
    • negative regulation of transforming growth factor beta receptor signaling pathway
  • performs the following molecular functions:
    • calcium ion binding
  • is located in the following cellular components:
    • proteinaceous extracellular matrix

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Aspn indicates that it:
  • participates in the following biological processes:
    • biomineral tissue development
  • performs the following molecular functions:
    • porin activity
  • is located in the following cellular components:
    • extracellular region
    • pore complex

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References

1. Lorenzo P et al. (2001) Identification and characterization of asporin. a novel member of the leucine-rich repeat protein family closely related to decorin and biglycan. J Biol Chem, 276:12201-11. (PubMed:11152692)
2. Nakajima M et al. (2007) Mechanisms for asporin function and regulation in articular cartilage. J Biol Chem, 282:32185-92. (PubMed:17827158)
3. Yamada S et al. (2007) PLAP-1/asporin, a novel negative regulator of periodontal ligament mineralization. J Biol Chem, 282:23070-80. (PubMed:17522060)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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