Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Fkbp11. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] FKBP11 belongs to the FKBP family of peptidyl-prolyl cis/trans isomerases, which catalyze the folding of proline-containing polypeptides. The peptidyl-prolyl isomerase activity of FKBP proteins is inhibited by the immunosuppressant compounds FK506 and rapamycin (Rulten et al., 2006 [PubMed 16596453]).[supplied by OMIM, Mar 2008]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Fkbp11:
  • participates in the following biological processes:
    • peptidyl-proline modification
  • performs the following molecular functions:
    • FK506 binding
    • peptidyl-prolyl cis-trans isomerase activity
  • is located in the following cellular components:
    • membrane

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Summary text based on GO annotations supported by structural data

• Fkbp11 encodes a protein or proteins that contain the following InterPro domains: Peptidyl-prolyl cis-trans isomerase, FKBP-type, Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain, indicating that the gene product:
  • participates in the following biological processes:
    • protein folding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Fkbp11 indicates that it:
  • participates in the following biological processes:
    • protein folding
  • performs the following molecular functions:
    • isomerase activity
  • is located in the following cellular components:
    • integral to membrane

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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