Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Sharpin. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary text based on GO annotations supported by experimental evidence in mouse

• The gene product of Sharpin has been shown to bind to the gene products of Eya1, Eya2. ^[3]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Sharpin
  • participates in the following biological processes:
    • apoptotic nuclear changes ^[2]
    • epidermis development ^[2]
    • keratinization ^[2]
    • mitochondrion organization ^[2]
    • negative regulation of inflammatory response ^{[1, 4]}
    • positive regulation of I-kappaB kinase/NF-kappaB cascade ^{[1, 4]}
    • regulation of tumor necrosis factor-mediated signaling pathway ^{[1, 4]}

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Sharpin:
  • participates in the following biological processes:
    • positive regulation of I-kappaB kinase/NF-kappaB cascade
    • protein homooligomerization
    • protein linear polyubiquitination
    • regulation of CD40 signaling pathway
    • regulation of tumor necrosis factor-mediated signaling pathway
  • performs the following molecular functions:
    • identical protein binding
    • polyubiquitin binding
    • protein complex binding
  • is located in the following cellular components:
    • cytosol
    • dendrite
    • LUBAC complex
    • postsynaptic density

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Summary text based on GO annotations supported by structural data

• Sharpin encodes a protein or proteins that contain the following InterPro domains: SHARPIN, Zinc finger, RanBP2-type, indicating that the gene product:
  • performs the following molecular functions:
    • zinc ion binding
  • is located in the following cellular components:
    • intracellular

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Sharpin indicates that it:
  • performs the following molecular functions:
    • metal ion binding
  • is located in the following cellular components:
    • cytoplasm

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References

1. Gerlach B et al. (2011) Linear ubiquitination prevents inflammation and regulates immune signalling. Nature, 471:591-6. (PubMed:21455173)
2. Gijbels MJ et al. (1995) Ultrastructure of epidermis of mice with chronic proliferative dermatitis. Ultrastruct Pathol, 19:107-11. (PubMed:7792947)
3. Landgraf K et al. (2010) Sipl1 and Rbck1 are novel Eya1-binding proteins with a role in craniofacial development. Mol Cell Biol, 30:5764-75. (PubMed:20956555)
4. Tokunaga F et al. (2011) SHARPIN is a component of the NF-kappaB-activating linear ubiquitin chain assembly complex. Nature, 471:633-6. (PubMed:21455180)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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