Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables protein-macromolecule adaptor activity. Involved in negative regulation of inflammatory response; positive regulation of canonical NF-kappaB signal transduction; and regulation of tumor necrosis factor-mediated signaling pathway. Acts upstream of or within apoptotic nuclear changes; keratinization; and mitochondrion organization. Part of LUBAC complex. Is expressed in several structures, including cochlear ganglion; genitourinary system; heart; inner ear epithelium; and lung. Used to study atopic dermatitis. Orthologous to human SHARPIN (SHANK associated RH domain interactor).