Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables peptidase activity. Acts upstream of or within blood coagulation. Located in extracellular space. Is expressed in embryo; liver; and liver lobe. Used to study factor XII deficiency. Human ortholog(s) of this gene implicated in angioedema (multiple); cerebrovascular disease (multiple); factor XII deficiency; and myocardial infarction. Orthologous to human F12 (coagulation factor XII).