Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of F12. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of March 7, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of F12
  • participates in the following biological processes:
    • blood coagulation ^[2]
    • metabolic process ^[2]
    • regulation of blood coagulation ^[1]
  • performs the following molecular functions:
    • peptidase activity ^[2]
  • is located in the following cellular components:
    • extracellular space ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of F12:
  • participates in the following biological processes:
    • blood coagulation
    • Factor XII activation
    • plasma kallikrein-kinin cascade
    • positive regulation of blood coagulation
    • positive regulation of fibrinolysis
    • positive regulation of plasminogen activation
    • protein autoprocessing
    • protein processing
    • response to misfolded protein
    • zymogen activation
  • performs the following molecular functions:
    • serine-type aminopeptidase activity
    • serine-type endopeptidase activity
  • is located in the following cellular components:
    • extracellular space

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Summary text based on GO annotations supported by structural data

• F12 encodes a protein or proteins that contain the following InterPro domains: Coagulation factor XIIa/hepatocyte growth factor activator, EGF-like, conserved site, Epidermal growth factor-like domain, Fibronectin, type I, Fibronectin, type II, collagen-binding, Kringle, Kringle, conserved site, Kringle-like fold, Peptidase cysteine/serine, trypsin-like, Peptidase S1/S6, chymotrypsin/Hap, Peptidase S1/S6, chymotrypsin/Hap, active site, Peptidase S1A, chymotrypsin-type, indicating that the gene product:
  • participates in the following biological processes:
    • proteolysis
  • performs the following molecular functions:
    • catalytic activity
  • is located in the following cellular components:
    • extracellular region

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe F12 indicates that it:
  • participates in the following biological processes:
    • fibrinolysis
    • hemostasis
    • proteolysis
  • performs the following molecular functions:
    • hydrolase activity
    • serine-type peptidase activity
  • is located in the following cellular components:
    • extracellular region

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References

1. Kleinschnitz C et al. (2006) Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis. J Exp Med, 203:513-8. (PubMed:16533887)
2. Pauer HU et al. (2004) Targeted deletion of murine coagulation factor XII gene-a model for contact phase activation in vivo. Thromb Haemost, 92:503-8. (PubMed:15351846)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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