Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Il21. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Il21
  • participates in the following biological processes:
    • positive regulation of interferon-gamma biosynthetic process ^[1]
    • positive regulation of interleukin-10 production ^[1]
    • positive regulation of natural killer cell cytokine production ^[1]
    • positive regulation of natural killer cell differentiation ^[1]
    • positive regulation of natural killer cell mediated cytotoxicity ^[1]
  • performs the following molecular functions:
    • cytokine receptor binding ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Il21:
  • participates in the following biological processes:
    • cell maturation
    • positive regulation of B cell proliferation
    • positive regulation of cell proliferation
    • positive regulation of interleukin-17 production
    • positive regulation of T cell proliferation
    • positive regulation of tyrosine phosphorylation of Stat1 protein
    • positive regulation of tyrosine phosphorylation of Stat3 protein
  • performs the following molecular functions:
    • interleukin-2 receptor binding

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Summary text based on GO annotations supported by structural data

• Il21 encodes a protein or proteins that contain the following InterPro domains: Interleukin-15-like, indicating that the gene product:
  • participates in the following biological processes:
    • immune response
  • is located in the following cellular components:
    • extracellular region

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Il21 indicates that it:
  • performs the following molecular functions:
    • cytokine activity
  • is located in the following cellular components:
    • extracellular region
    • extracellular space

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References

1. Brady J et al. (2004) IL-21 induces the functional maturation of murine NK cells. J Immunol, 172:2048-58. (PubMed:14764669)
2. Parrish-Novak J et al. (2000) Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function Nature, 408:57-63. (PubMed:11081504)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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