Automated description from the Alliance of Genome Resources
Exhibits ubiquitin protein ligase binding activity. Involved in establishment of planar polarity; establishment or maintenance of epithelial cell apical/basal polarity; and regulation of postsynaptic membrane neurotransmitter receptor levels. Localizes to several cellular components, including the AMPA glutamate receptor complex; bicellular tight junction; and glutamatergic synapse. Predicted to colocalize with the ionotropic glutamate receptor complex. Used to study non-syndromic X-linked intellectual disability. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability. Is expressed in central nervous system and retina. Orthologous to human DLG3 (discs large MAGUK scaffold protein 3).