Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits aminophospholipid flippase activity and cardiolipin binding activity. Involved in several processes, including aminophospholipid transport; bile acid metabolic process; and nervous system development. Localizes to plasma membrane and stereocilium. Is expressed in adrenal gland; alimentary system; and liver. Used to study intrahepatic cholestasis. Human ortholog(s) of this gene implicated in benign recurrent intrahepatic cholestasis 1; intrahepatic cholestasis; intrahepatic cholestasis of pregnancy 1; and progressive familial intrahepatic cholestasis 1. Orthologous to human ATP8B1 (ATPase phospholipid transporting 8B1).