Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables aminophospholipid flippase activity and cardiolipin binding activity. Involved in several processes, including lipid transport; nervous system development; and sensory perception of sound. Acts upstream of or within bile acid metabolic process. Located in plasma membrane and stereocilium. Is expressed in adrenal gland; alimentary system; and liver. Human ortholog(s) of this gene implicated in benign recurrent intrahepatic cholestasis 1; intrahepatic cholestasis; intrahepatic cholestasis of pregnancy 1; and progressive familial intrahepatic cholestasis 1. Orthologous to human ATP8B1 (ATPase phospholipid transporting 8B1).