Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Tuba8. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 9, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the alpha tubulin protein family. Alpha tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Mutations in this gene are associated with polymicrogyria and optic nerve hypoplasia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Tuba8:
  • participates in the following biological processes:
    • microtubule cytoskeleton organization
  • performs the following molecular functions:
    • structural constituent of cytoskeleton
  • is located in the following cellular components:
    • microtubule

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Summary text based on GO annotations supported by structural data

• Tuba8 encodes a protein or proteins that contain the following InterPro domains: Alpha tubulin, Tubulin, Tubulin, C-terminal, Tubulin, conserved site, Tubulin/FtsZ, 2-layer sandwich domain, Tubulin/FtsZ, C-terminal, Tubulin/FtsZ, GTPase domain, indicating that the gene product:
  • participates in the following biological processes:
    • GTP catabolic process
    • microtubule-based process
    • protein polymerization
  • performs the following molecular functions:
    • GTP binding
    • GTPase activity
  • is located in the following cellular components:
    • protein complex

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Tuba8 indicates that it:
  • performs the following molecular functions:
    • GTP binding
    • nucleotide binding
  • is located in the following cellular components:
    • cytoplasm
    • cytoskeleton

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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