Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables protein serine/threonine kinase activity. Involved in canonical NF-kappaB signal transduction and immune response. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Is expressed in several structures, including alimentary system; cardiovascular system; nervous system; sensory organ; and skeleton. Used to study Sjogren's syndrome and primary biliary cholangitis. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human MAP3K14 (mitogen-activated protein kinase kinase kinase 14).