Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Nucb2. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. This protein binds calcium and has EF-folding domains. [provided by RefSeq, Oct 2011]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Nucb2
  • performs the following molecular functions:
    • calcium ion binding ^[1]
  • is located in the following cellular components:
    • cytoplasm ^[1]
    • endoplasmic reticulum ^[1]
    • nuclear outer membrane ^[1]
    • nucleus ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Nucb2:
  • performs the following molecular functions:
    • tumor necrosis factor receptor binding
  • is located in the following cellular components:
    • endoplasmic reticulum-Golgi intermediate compartment
    • Golgi apparatus
    • Golgi medial cisterna

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Nucb2 indicates that it:
  • performs the following molecular functions:
    • DNA binding
    • metal ion binding
  • is located in the following cellular components:
    • extracellular region
    • membrane

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References

1. Taniguchi N et al. (2000) The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm J Biol Chem, 275:31674-81. (PubMed:10915798)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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