Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Phgdh. (This text reflects annotations as of Wednesday, January 23, 2013.)

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known. [provided by RefSeq, Aug 2011]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Phgdh
  • participates in the following biological processes:
    • cell cycle process ^[1]
    • gamma-aminobutyric acid metabolic process ^[1]
    • glial cell development ^[1]
    • glutamine metabolic process ^[1]
    • glycine metabolic process ^[1]
    • L-serine metabolic process ^[1]
    • neural tube development ^[1]
    • neurogenesis ^[1]
    • neuron projection development ^[1]
    • regulation of gene expression ^[1]
    • spinal cord development ^[1]
    • taurine metabolic process ^[1]
    • threonine metabolic process ^[1]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Phgdh:
  • participates in the following biological processes:
    • oxidation-reduction process
  • performs the following molecular functions:
    • phosphoglycerate dehydrogenase activity

---

Summary text based on GO annotations supported by structural data

• Phgdh encodes a protein or proteins that contain the following InterPro domains: D-3-phosphoglycerate dehydrogenase, D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain, D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding, NAD(P)-binding domain, indicating that the gene product:
  • participates in the following biological processes:
    • L-serine biosynthetic process
    • metabolic process
  • performs the following molecular functions:
    • cofactor binding
    • NAD binding
    • nucleotide binding
    • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Phgdh indicates that it:
  • participates in the following biological processes:
    • cellular amino acid biosynthetic process
    • L-serine biosynthetic process
  • performs the following molecular functions:
    • oxidoreductase activity

---

References

1. Kawakami Y et al. (2009) Impaired neurogenesis in embryonic spinal cord of Phgdh knockout mice, a serine deficiency disorder model. Neurosci Res, 63:184-93. (PubMed:19114063)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---