Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables SMAD binding activity and type II activin receptor binding activity. Involved in several processes, including SMAD protein signal transduction; neuroligin clustering involved in postsynaptic membrane assembly; and positive regulation of synaptic vesicle clustering. Acts upstream of or within signal transduction. Located in several cellular components, including centriole; ciliary base; and photoreceptor inner segment. Is expressed in several structures, including branchial arch; genitourinary system; limb; nervous system; and vibrissa. Human ortholog(s) of this gene implicated in nephrotic syndrome type 15. Orthologous to human MAGI2 (membrane associated guanylate kinase, WW and PDZ domain containing 2).