Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Polg2. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of May 18, 2009. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the processivity subunit of the mitochondrial DNA polymerase gamma. The encoded protein forms a heterotrimer containing one catalytic subunit and two processivity subunits. This protein enhances DNA binding and promotes processive DNA synthesis. Mutations in this gene result in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions.[provided by RefSeq, Sep 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Polg2
  • participates in the following biological processes:
    • metabolic process ^[1]
  • performs the following molecular functions:
    • DNA-directed DNA polymerase activity ^[1]
  • is located in the following cellular components:
    • mitochondrion ^{[3, 4]}
• Researchers have inferred, based on physical interactions, that the gene product of Polg2
  • performs the following molecular functions:
    • identical protein binding ^[2]
• Based on the experimental annotations above, MGI curators have inferred, that the gene product of Polg2
  • participates in the following biological processes:
    • DNA replication ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Polg2:
  • participates in the following biological processes:
    • metabolic process
  • performs the following molecular functions:
    • DNA-directed DNA polymerase activity
  • is located in the following cellular components:
    • mitochondrial nucleoid

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Summary text based on GO annotations supported by structural data

• Polg2 encodes a protein or proteins that contain the following InterPro domains: Anticodon-binding, Glycyl-tRNA synthetase, alpha2 dimer, indicating that the gene product:
  • participates in the following biological processes:
    • glycyl-tRNA aminoacylation
  • performs the following molecular functions:
    • ATP binding
    • glycine-tRNA ligase activity
    • nucleotide binding
  • is located in the following cellular components:
    • cytoplasm

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Polg2 indicates that it:
  • performs the following molecular functions:
    • DNA binding
    • nucleotidyltransferase activity
    • transferase activity

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References

1. Carrodeguas JA et al. (2000) Protein sequences conserved in prokaryotic aminoacyl-tRNA synthetases are important for the activity of the processivity factor of human mitochondrial DNA polymerase. Nucleic Acids Res, 28:1237-44. (PubMed:10666468)
2. Carrodeguas JA et al. (2001) Crystal structure and deletion analysis show that the accessory subunit of mammalian DNA polymerase gamma, Pol gamma B, functions as a homodimer. Mol Cell, 7:43-54. (PubMed:11172710)
3. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell, 115:629-40. (PubMed:14651853)
4. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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