Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Rgs11. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of March 8, 2007. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Rgs11
  • is located in the following cellular components:
    • dendrite terminus ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Rgs11:
  • performs the following molecular functions:
    • GTPase activator activity
  • is located in the following cellular components:
    • cytoplasm
    • plasma membrane
    • protein complex

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Summary text based on GO annotations supported by structural data

• Rgs11 encodes a protein or proteins that contain the following InterPro domains: DEP domain, G-protein gamma-like domain, Regulator of G protein signalling, Regulator of G protein signalling superfamily, Regulator of G-protein signaling, domain 1, Winged helix-turn-helix transcription repressor DNA-binding, indicating that the gene product:
  • participates in the following biological processes:
    • intracellular signal transduction
    • termination of G-protein coupled receptor signaling pathway
  • performs the following molecular functions:
    • signal transducer activity
  • is located in the following cellular components:
    • heterotrimeric G-protein complex

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Rgs11 indicates that it:
  • participates in the following biological processes:
    • negative regulation of signal transduction

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References

1. Drenan RM et al. (2005) Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family. J Cell Biol, 169:623-33. (PubMed:15897264)
2. Orlandi C et al. (2012) GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes. J Cell Biol, 197:711-9. (PubMed:22689652)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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