Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables several functions, including NAD+-protein-arginine ADP-ribosyltransferase activity; NAD-dependent histone deacetylase activity; and TORC2 complex binding activity. Involved in several processes, including positive regulation of cell population proliferation; regulation of nucleobase-containing compound metabolic process; and regulation of protein localization. Located in nucleus. Part of chromatin. Is expressed in several structures, including alimentary system; central nervous system; gonad; musculature; and retina. Used to study progeria. Orthologous to human SIRT6 (sirtuin 6).