Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cngb3. (This text reflects annotations as of Thursday, January 16, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the beta subunit of a cyclic nucleotide-gated ion channel. The encoded beta subunit appears to play a role in modulation of channel function in cone photoreceptors. This heterotetrameric channel is necessary for sensory transduction, and mutations in this gene have been associated with achromatopsia 3, progressive cone dystrophy, and juvenile macular degeneration, also known as Stargardt Disease. [provided by RefSeq, Feb 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Cngb3
  • is located in the following cellular components:
    • photoreceptor outer segment ^[2]
• The gene product of Cngb3 has been shown to bind to the gene products of Cnga3. ^[1] Researchers have inferred, based on physical interactions, that the gene product of Cngb3
  • participates in the following biological processes:
    • cation transport ^[1]
    • ion transmembrane transport ^[1]
  • performs the following molecular functions:
    • intracellular cGMP activated cation channel activity ^[1]
• Based on the experimental annotations above, MGI curators have inferred, that the gene product of Cngb3
  • participates in the following biological processes:
    • cyclic nucleotide metabolic process ^[1]
  • performs the following molecular functions:
    • cGMP binding ^[1]
  • is located in the following cellular components:
    • plasma membrane ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Cngb3:
  • participates in the following biological processes:
    • phototransduction, visible light
    • potassium ion transmembrane transport
    • regulation of ion transmembrane transport
    • regulation of membrane potential
  • performs the following molecular functions:
    • cGMP binding
    • intracellular cAMP activated cation channel activity
    • voltage-gated potassium channel activity
  • is located in the following cellular components:
    • integral component of plasma membrane

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Summary text based on GO annotations supported by structural data

• Cngb3 encodes a protein or proteins that contain the following InterPro domains: Cyclic nucleotide-binding domain, Cyclic nucleotide-binding, conserved site, Cyclic nucleotide-binding-like, Ion transport domain, RmlC-like jelly roll fold, indicating that the gene product:
  • participates in the following biological processes:
    • ion transport
    • transmembrane transport
  • performs the following molecular functions:
    • ion channel activity
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Cngb3 indicates that it:
  • participates in the following biological processes:
    • ion transport
    • response to stimulus
    • transport
    • visual perception
  • performs the following molecular functions:
    • nucleotide binding
  • is located in the following cellular components:
    • integral component of membrane
    • membrane

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References

1. Gerstner A et al. (2000) Molecular cloning and functional characterization of a new modulatory cyclic nucleotide-gated channel subunit from mouse retina. J Neurosci, 20:1324-32. (PubMed:10662822)
2. Huttl S et al. (2005) Impaired channel targeting and retinal degeneration in mice lacking the cyclic nucleotide-gated channel subunit CNGB1. J Neurosci, 25:130-8. (PubMed:15634774)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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