Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Slc25a4. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Mutations in this gene have been shown to result in autosomal dominant progressive external opthalmoplegia and familial hypertrophic cardiomyopathy. [provided by RefSeq, Sep 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Slc25a4
  • is located in the following cellular components:
    • mitochondrial inner membrane ^[2]
    • mitochondrion ^[3]
• The gene product of Slc25a4 has been shown to bind to the gene products of Arl2bp. ^[4]
• Researchers have inferred, based on genetic interactions, that the gene product of Slc25a4
  • participates in the following biological processes:
    • apoptotic mitochondrial changes based on interactions with Hk2, Ppif ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Slc25a4:
  • participates in the following biological processes:
    • ADP transport
    • ATP transport
    • negative regulation of necrotic cell death
    • positive regulation of oxidative phosphorylation uncoupler activity
  • performs the following molecular functions:
    • ATP:ADP antiporter activity
    • enzyme binding
  • is located in the following cellular components:
    • mitochondrial inner membrane
    • mitochondrial outer membrane
    • mitochondrion

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Summary text based on GO annotations supported by structural data

• Slc25a4 encodes a protein or proteins that contain the following InterPro domains: Adenine nucleotide translocator 1, Mitochondrial carrier domain, Mitochondrial carrier protein, Mitochondrial substrate/solute carrier, indicating that the gene product:
  • participates in the following biological processes:
    • transmembrane transport
    • transport
  • performs the following molecular functions:
    • transporter activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Slc25a4 indicates that it:
  • participates in the following biological processes:
    • transport
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Chiara F et al. (2008) Hexokinase II detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channels. PLoS ONE, 3:e1852. (PubMed:18350175)
2. Da Cruz S et al. (2003) Proteomic analysis of the mouse liver mitochondrial inner membrane. J Biol Chem, 278:41566-71. (PubMed:12865426)
3. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)
4. Sharer JD et al. (2002) ARL2 and BART enter mitochondria and bind the adenine nucleotide transporter. Mol Biol Cell, 13:71-83. (PubMed:11809823)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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