Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Aldh1a1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet. [provided by RefSeq, Mar 2011]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Aldh1a1
  • participates in the following biological processes:
    • 9-cis-retinoic acid biosynthetic process ^[8]
    • oxidation-reduction process ^[4]
    • response to drug ^[3]
    • retinoic acid metabolic process ^[2]
  • performs the following molecular functions:
    • 3-chloroallyl aldehyde dehydrogenase activity ^[4]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Aldh1a1
  • participates in the following biological processes:
    • retinoic acid metabolic process ^{[1, 5, 6]}
    • retinol metabolic process ^[6]
• Researchers have inferred, based on genetic interactions, that the gene product of Aldh1a1
  • participates in the following biological processes:
    • embryonic eye morphogenesis based on interactions with Aldh1a3 ^{[5, 7]}
    • optic cup morphogenesis involved in camera-type eye development based on interactions with Aldh1a3 ^[7]
    • positive regulation of apoptotic process based on interactions with Aldh1a3 ^{[5, 7]}
    • retinoic acid metabolic process based on interactions with Aldh1a3 ^[5]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Aldh1a1:
  • participates in the following biological processes:
    • 9-cis-retinoic acid metabolic process
    • oxidation-reduction process
    • protein homotetramerization
    • response to ethanol
    • response to oxidative stress
    • retinoic acid biosynthetic process
  • performs the following molecular functions:
    • aldehyde dehydrogenase (NAD) activity
    • benzaldehyde dehydrogenase (NAD+) activity
    • identical protein binding
    • retinal dehydrogenase activity
  • is located in the following cellular components:
    • cytoplasm
    • nucleus

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Summary text based on GO annotations supported by structural data

• Aldh1a1 encodes a protein or proteins that contain the following InterPro domains: Aldehyde dehydrogenase domain, Aldehyde dehydrogenase, C-terminal, Aldehyde dehydrogenase, conserved site, Aldehyde dehydrogenase, N-terminal, Aldehyde/histidinol dehydrogenase, indicating that the gene product:
  • participates in the following biological processes:
    • metabolic process
  • performs the following molecular functions:
    • oxidoreductase activity
    • oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Aldh1a1 indicates that it:
  • performs the following molecular functions:
    • oxidoreductase activity

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References

1. Fan X et al. (2003) Targeted disruption of Aldh1a1 (Raldh1) provides evidence for a complex mechanism of retinoic acid synthesis in the developing retina. Mol Cell Biol, 23:4637-48. (PubMed:12808103)
2. Hsu LC et al. (1999) Molecular analysis of two closely related mouse aldehyde dehydrogenase genes: identification of a role for Aldh1, but not Aldh-pb, in the biosynthesis of retinoic acid. Biochem J, 339:387-95. (PubMed:10191271)
3. Levi BP et al. (2009) Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems. Blood, 113:1670-80. (PubMed:18971422)
4. Maly IP et al. (2003) The so-called 'testis-specific aldehyde dehydrogenase' corresponds to type 2 retinaldehyde dehydrogenase in the mouse. Histochem Cell Biol, 119:169-74. (PubMed:12610736)
5. Matt N et al. (2005) Retinoic acid-dependent eye morphogenesis is orchestrated by neural crest cells. Development, 132:4789-800. (PubMed:16207763)
6. Molotkov A et al. (2003) Genetic evidence that retinaldehyde dehydrogenase Raldh1 (Aldh1a1) functions downstream of alcohol dehydrogenase Adh1 in metabolism of retinol to retinoic acid. J Biol Chem, 278:36085-90. (PubMed:12851412)
7. Molotkov A et al. (2006) Retinoic acid guides eye morphogenetic movements via paracrine signaling but is unnecessary for retinal dorsoventral patterning. Development, 133:1901-10. (PubMed:16611695)
8. Zhuang R et al. (2002) cis-Retinol/androgen dehydrogenase, isozyme 3 (CRAD3): a short-chain dehydrogenase active in a reconstituted path of 9-cis-retinoic acid biosynthesis in intact cells. Biochemistry, 41:3477-83. (PubMed:11876656)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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