Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Slco1a5. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 9, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2008]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Slco1a5:
  • participates in the following biological processes:
    • bile acid and bile salt transport
    • intestinal absorption
    • monocarboxylic acid transport
    • organic anion transport
    • thyroid hormone transport
  • performs the following molecular functions:
    • bile acid transmembrane transporter activity
    • monocarboxylic acid transmembrane transporter activity
    • organic anion transmembrane transporter activity
    • thyroid hormone transmembrane transporter activity
  • is located in the following cellular components:
    • brush border membrane
    • integral to plasma membrane

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Summary text based on GO annotations supported by structural data

• Slco1a5 encodes a protein or proteins that contain the following InterPro domains: Kazal-type serine protease inhibitor domain, Major facilitator superfamily domain, Major facilitator superfamily domain, general substrate transporter, Organic anion transporter polypeptide OATP, Proteinase inhibitor I1, Kazal, indicating that the gene product:
  • participates in the following biological processes:
    • transport
  • performs the following molecular functions:
    • transporter activity
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Slco1a5 indicates that it:
  • participates in the following biological processes:
    • ion transport
    • transport
  • is located in the following cellular components:
    • integral to membrane
    • membrane
    • plasma membrane

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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