Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Atic. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 9, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria. [provided by RefSeq, Sep 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Atic
  • is located in the following cellular components:
    • mitochondrion ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Atic:
  • participates in the following biological processes:
    • 'de novo' IMP biosynthetic process
    • dihydrofolate metabolic process
    • nucleoside metabolic process
    • ribonucleotide metabolic process
    • tetrahydrofolate biosynthetic process
  • performs the following molecular functions:
    • IMP cyclohydrolase activity
    • phosphoribosylaminoimidazolecarboxamide formyltransferase activity
    • protein homodimerization activity

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Summary text based on GO annotations supported by structural data

• Atic encodes a protein or proteins that contain the following InterPro domains: AICAR transformylase domain, AICAR transformylase, insert domain, AICARFT/IMPCHase bienzyme, Cytidine deaminase-like, Methylglyoxal synthase-like domain, indicating that the gene product:
  • participates in the following biological processes:
    • purine nucleotide biosynthetic process
  • performs the following molecular functions:
    • catalytic activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Atic indicates that it:
  • participates in the following biological processes:
    • metabolic process
    • purine nucleotide biosynthetic process
  • performs the following molecular functions:
    • catalytic activity
    • hydrolase activity
    • transferase activity

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References

1. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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