Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Pla2g7. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a secreted enzyme that catalyzes the degradation of platelet-activating factor to biologically inactive products. Defects in this gene are a cause of platelet-activating factor acetylhydrolase deficiency. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2009]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Pla2g7:
  • participates in the following biological processes:
    • lipid oxidation
    • low-density lipoprotein particle remodeling
    • plasma lipoprotein particle oxidation
    • positive regulation of monocyte chemotaxis
  • performs the following molecular functions:
    • calcium-independent phospholipase A2 activity
    • phospholipid binding
  • is located in the following cellular components:
    • low-density lipoprotein particle

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Summary text based on GO annotations supported by structural data

• Pla2g7 encodes a protein or proteins that contain the following InterPro domains: PAF acetylhydrolase, Platelet-activating factor acetylhydrolase, indicating that the gene product:
  • participates in the following biological processes:
    • lipid catabolic process
  • performs the following molecular functions:
    • 1-alkyl-2-acetylglycerophosphocholine esterase activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Pla2g7 indicates that it:
  • participates in the following biological processes:
    • lipid catabolic process
    • lipid metabolic process
  • performs the following molecular functions:
    • hydrolase activity
  • is located in the following cellular components:
    • extracellular region
• Pla2g7 has been associated with the Enzyme Commission numbers: 3.1.1.47, which implies that the gene product:
  • performs the following molecular functions:
    • 1-alkyl-2-acetylglycerophosphocholine esterase activity

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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