Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Foxd3. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. Mutations in this gene cause autoimmune susceptibility 1. [provided by RefSeq, Nov 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Foxd3
  • participates in the following biological processes:
    • in utero embryonic development ^[2]
    • negative regulation of transcription from RNA polymerase II promoter ^[3]
  • performs the following molecular functions:
    • sequence-specific DNA binding transcription factor activity ^[3]
    • transcription regulatory region DNA binding ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Foxd3
  • participates in the following biological processes:
    • embryonic placenta development ^[4]
    • trophectodermal cell differentiation ^[4]
• Based on the experimental annotations above, MGI curators have inferred, that the gene product of Foxd3
  • is located in the following cellular components:
    • nucleus ^[3]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Foxd3:
  • participates in the following biological processes:
    • axon extension involved in axon guidance
    • branching involved in ureteric bud morphogenesis
    • cartilage development
    • enteric nervous system development
    • iridophore differentiation
    • kidney development
    • lateral line nerve glial cell development
    • melanocyte differentiation
    • negative regulation of transcription from RNA polymerase II promoter
    • neural crest cell migration
    • pattern specification process
    • peripheral nervous system development
    • positive regulation of transcription from RNA polymerase II promoter
    • regulation of sequence-specific DNA binding transcription factor activity
    • sympathetic nervous system development
  • performs the following molecular functions:
    • DNA binding
    • DNA binding, bending
    • double-stranded DNA binding
    • RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
    • RNA polymerase II regulatory region sequence-specific DNA binding
    • RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
    • transcription factor binding
  • is located in the following cellular components:
    • nuclear chromatin
    • transcription factor complex

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Summary text based on GO annotations supported by structural data

• Foxd3 encodes a protein or proteins that contain the following InterPro domains: Transcription factor, fork head, Transcription factor, fork head, conserved site, Winged helix-turn-helix transcription repressor DNA-binding, indicating that the gene product:
  • participates in the following biological processes:
    • regulation of transcription, DNA-dependent
  • performs the following molecular functions:
    • sequence-specific DNA binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Foxd3 indicates that it:
  • participates in the following biological processes:
    • multicellular organismal development
    • regulation of transcription, DNA-dependent

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References

1. Clevidence DE et al. (1994) Members of the HNF-3/forkhead family of transcription factors exhibit distinct cellular expression patterns in lung and regulate the surfactant protein B promoter. Dev Biol, 166:195-209. (PubMed:7958446)
2. Hanna LA et al. (2002) Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo. Genes Dev, 16:2650-61. (PubMed:12381664)
3. Sutton J et al. (1996) Genesis, a winged helix transcriptional repressor with expression restricted to embryonic stem cells. J Biol Chem, 271:23126-33. (PubMed:8798505)
4. Tompers DM et al. (2005) Foxd3 is required in the trophoblast progenitor cell lineage of the mouse embryo. Dev Biol, 285:126-37. (PubMed:16039639)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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