Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Abcg2. (This text reflects annotations as of Wednesday, January 23, 2013.)

---

Summary from NCBI RefSeq

The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, the human protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. This protein likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. [provided by RefSeq, Jul 2008]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Abcg2:
  • participates in the following biological processes:
    • drug export
    • drug transmembrane transport
    • drug transport
    • embryonic process involved in female pregnancy
    • urate metabolic process
  • performs the following molecular functions:
    • drug transmembrane transporter activity
    • protein dimerization activity
    • protein homodimerization activity
  • is located in the following cellular components:
    • apical plasma membrane
    • membrane
    • nucleus

---

Summary text based on GO annotations supported by structural data

• Abcg2 encodes a protein or proteins that contain the following InterPro domains: AAA+ ATPase domain, ABC transporter-like, ABC-2 type transporter, indicating that the gene product:
  • performs the following molecular functions:
    • ATP binding
    • ATPase activity
    • nucleoside-triphosphatase activity
    • nucleotide binding

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Abcg2 indicates that it:
  • participates in the following biological processes:
    • transport
  • performs the following molecular functions:
    • ATP binding
    • nucleotide binding
  • is located in the following cellular components:
    • integral to membrane
    • plasma membrane

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---