Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables JUN kinase kinase kinase activity; MAP kinase kinase activity; and cytoskeletal protein binding activity. Acts upstream of or within several processes, including eyelid development in camera-type eye; positive regulation of actin filament polymerization; and transforming growth factor beta receptor signaling pathway. Part of filamentous actin. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in 46,XY sex reversal 6; breast cancer; gastrointestinal system cancer (multiple); and lung non-small cell carcinoma. Orthologous to human MAP3K1 (mitogen-activated protein kinase kinase kinase 1).