Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Sgcb. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the sarcoglycan family. Sarcoglycans are transmembrane components in the dystrophin-glycoprotein complex which help stabilize the muscle fiber membranes and link the muscle cytoskeleton to the extracellular matrix. Mutations in this gene have been associated with limb-girdle muscular dystrophy.[provided by RefSeq, Oct 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Sgcb
  • participates in the following biological processes:
    • cardiac cell differentiation ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Sgcb:
  • is located in the following cellular components:
    • dystrophin-associated glycoprotein complex

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Summary text based on GO annotations supported by structural data

• Sgcb encodes a protein or proteins that contain the following InterPro domains: Sarcoglycan complex subunit protein, indicating that the gene product:
  • participates in the following biological processes:
    • cytoskeleton organization
  • is located in the following cellular components:
    • integral to membrane
    • sarcoglycan complex

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Sgcb indicates that it:
  • is located in the following cellular components:
    • cytoplasm
    • cytoskeleton
    • integral to membrane
    • membrane
    • plasma membrane

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References

1. Lague MN et al. (2010) Decidual PTEN expression is required for trophoblast invasion in the mouse. Am J Physiol Endocrinol Metab, 299:E936-46. (PubMed:20858757)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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