Automated description from the Alliance of Genome Resources (Release 5.2.2)
Enables endopeptidase activity; extracellular matrix binding activity; and heparin binding activity. Involved in extracellular matrix disassembly; myoblast fusion; and negative regulation of cold-induced thermogenesis. Acts upstream of or within defense response to bacterium. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and immune system. Human ortholog(s) of this gene implicated in osteoarthritis. Orthologous to human ADAMTS5 (ADAM metallopeptidase with thrombospondin type 1 motif 5).