Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Tshz1. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of March 22, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a colon cancer antigen that was defined by serological analysis of recombinant cDNA expression libraries. The encoded protein is a member of the teashirt C2H2-type zinc-finger protein family and may be involved in transcriptional regulation of developmental processes. Mutations in this gene may be associated with congenital aural atresia syndrome. [provided by RefSeq, Jan 2012]

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Summary text based on GO annotations supported by experimental evidence in mouse

• The gene product of Tshz1 has been shown to bind to the gene products of Apbb1. ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Tshz1
  • participates in the following biological processes:
    • anterior/posterior pattern specification ^[1]
    • middle ear morphogenesis ^[1]
    • soft palate development ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Tshz1:
  • is located in the following cellular components:
    • nucleus

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Summary text based on GO annotations supported by structural data

• Tshz1 encodes a protein or proteins that contain the following InterPro domains: Homeodomain, Homeodomain-like, Teashirt homologue 1, Zinc finger, C2H2, Zinc finger, C2H2-like, indicating that the gene product:
  • participates in the following biological processes:
    • regulation of transcription, DNA-dependent
  • performs the following molecular functions:
    • DNA binding
    • sequence-specific DNA binding
    • sequence-specific DNA binding transcription factor activity
    • zinc ion binding
  • is located in the following cellular components:
    • intracellular

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Tshz1 indicates that it:
  • participates in the following biological processes:
    • multicellular organismal development
    • regulation of transcription, DNA-dependent
    • transcription, DNA-dependent
  • performs the following molecular functions:
    • DNA binding
    • metal ion binding

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References

1. Core N et al. (2007) Tshz1 is required for axial skeleton, soft palate and middle ear development in mice. Dev Biol, 308:407-20. (PubMed:17586487)
2. Kajiwara Y et al. (2009) FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4. PLoS One, 4:e5071. (PubMed:19343227)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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