Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Grk1. (This text reflects annotations as of Wednesday, August 14, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Grk1
  • participates in the following biological processes:
    • negative regulation of apoptotic process ^[1]
    • photoreceptor cell morphogenesis ^[1]
    • positive regulation of phosphorylation ^[1]
    • post-embryonic retina morphogenesis in camera-type eye ^[1]
    • response to light stimulus ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Grk1:
  • participates in the following biological processes:
    • protein autophosphorylation
    • regulation of rhodopsin mediated signaling pathway
  • performs the following molecular functions:
    • rhodopsin kinase activity

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Summary text based on GO annotations supported by structural data

• Grk1 encodes a protein or proteins that contain the following InterPro domains: AGC-kinase, C-terminal, GPCR kinase, Protein kinase, ATP binding site, Protein kinase, catalytic domain, Protein kinase-like domain, Regulator of G protein signalling, Regulator of G protein signalling superfamily, Serine/threonine- / dual specificity protein kinase, catalytic domain, Serine/threonine-protein kinase, active site, indicating that the gene product:
  • participates in the following biological processes:
    • protein phosphorylation
    • signal transduction
    • termination of G-protein coupled receptor signaling pathway
  • performs the following molecular functions:
    • ATP binding
    • G-protein coupled receptor kinase activity
    • protein kinase activity
    • protein serine/threonine kinase activity
    • transferase activity, transferring phosphorus-containing groups

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Grk1 indicates that it:
  • participates in the following biological processes:
    • phosphorylation
    • protein phosphorylation
    • response to stimulus
    • visual perception
  • performs the following molecular functions:
    • ATP binding
    • kinase activity
    • nucleotide binding
    • protein serine/threonine kinase activity
    • transferase activity
  • is located in the following cellular components:
    • membrane

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References

1. Chen CK et al. (1999) Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase. Proc Natl Acad Sci U S A, 96:3718-22. (PubMed:10097103)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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