Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Spry2. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Spry2
  • participates in the following biological processes:
    • lung growth ^[3]
    • lung morphogenesis ^[3]
    • negative regulation of cell proliferation ^[2]
    • negative regulation of ERK1 and ERK2 cascade ^[2]
    • negative regulation of fibroblast growth factor receptor signaling pathway ^[2]
    • negative regulation of MAP kinase activity ^[4]
    • negative regulation of nerve growth factor receptor signaling pathway ^[2]
    • negative regulation of Ras GTPase activity ^[2]
    • negative regulation of Ras protein signal transduction ^[2]
    • respiratory system development ^[3]
• The gene product of Spry2 has been shown to bind to the gene products of Grb2, Spry1, Spry2, Spry4. ^{[2, 4]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Spry2
  • participates in the following biological processes:
    • branching morphogenesis of a tube ^[6]
    • cell fate commitment ^[5]
    • inner ear morphogenesis ^[5]
    • lung development ^[6]
    • negative regulation of apoptotic process ^[1]
    • sensory perception of sound ^[5]
• Researchers have inferred, based on genetic interactions, that the gene product of Spry2
  • participates in the following biological processes:
    • cell fate commitment based on interactions with Fgf8 ^[5]
    • inner ear morphogenesis based on interactions with Fgf8 ^[5]
    • negative regulation of fibroblast growth factor receptor signaling pathway based on interactions with Fgf8 ^[5]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Spry2:
  • participates in the following biological processes:
    • negative regulation of apoptotic process
    • negative regulation of peptidyl-threonine phosphorylation
    • positive regulation of ERK1 and ERK2 cascade
    • positive regulation of gene expression
    • positive regulation of peptidyl-serine phosphorylation
    • positive regulation of protein kinase B signaling cascade
    • positive regulation of protein serine/threonine kinase activity
  • performs the following molecular functions:
    • protein kinase binding
    • protein serine/threonine kinase activator activity

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Summary text based on GO annotations supported by structural data

• Spry2 encodes a protein or proteins that contain the following InterPro domains: Sprouty, indicating that the gene product:
  • participates in the following biological processes:
    • multicellular organismal development
    • regulation of signal transduction
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Spry2 indicates that it:
  • participates in the following biological processes:
    • multicellular organismal development
  • is located in the following cellular components:
    • cell projection
    • cytoplasm
    • cytoskeleton
    • membrane
    • microtubule
    • plasma membrane

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References

1. Edwin F et al. (2008) A novel role of Sprouty 2 in regulating cellular apoptosis. J Biol Chem, 283:3181-90. (PubMed:18070883)
2. Gross I et al. (2001) Mammalian sprouty proteins inhibit cell growth and differentiation by preventing ras activation. J Biol Chem, 276:46460-8. (PubMed:11585837)
3. Mailleux AA et al. (2001) Evidence that SPROUTY2 functions as an inhibitor of mouse embryonic lung growth and morphogenesis. Mech Dev, 102:81-94. (PubMed:11287183)
4. Ozaki K et al. (2005) Efficient suppression of FGF-2-induced ERK activation by the cooperative interaction among mammalian Sprouty isoforms. J Cell Sci, 118:5861-71. (PubMed:16339969)
5. Shim K et al. (2005) Sprouty2, a mouse deafness gene, regulates cell fate decisions in the auditory sensory epithelium by antagonizing FGF signaling. Dev Cell, 8:553-64. (PubMed:15809037)
6. Tefft JD et al. (1999) Conserved function of mSpry-2, a murine homolog of Drosophila sprouty, which negatively modulates respiratory organogenesis. Curr Biol, 9:219-22. (PubMed:10074434)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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