Automated description from the Alliance of Genome Resources
Exhibits formate-tetrahydrofolate ligase activity and methylenetetrahydrofolate dehydrogenase (NAD+) activity. Involved in several processes, including carboxylic acid metabolic process; neural tube closure; and neutrophil homeostasis. Localizes to the mitochondrion. Human ortholog(s) of this gene implicated in Down syndrome; cleft lip; cleft palate; neural tube defect (multiple); and tetralogy of Fallot. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human MTHFD1 (methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1).