Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables cholesterol 24-hydroxylase activity. Involved in cholesterol catabolic process and regulation of long-term synaptic potentiation. Acts upstream of with a negative effect on protein localization to membrane raft. Located in several cellular components, including dendrite; endoplasmic reticulum membrane; and postsynapse. Is expressed in several structures, including brain; genitourinary system; liver; retina; and spleen. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human CYP46A1 (cytochrome P450 family 46 subfamily A member 1).