Automated description from the Alliance of Genome Resources (Release 3.2)
Exhibits cholesterol 24-hydroxylase activity. Involved in cholesterol catabolic process; protein localization to membrane raft; and regulation of long-term synaptic potentiation. Localizes to several cellular components, including dendrite; endoplasmic reticulum membrane; and postsynapse. Is expressed in several structures, including central nervous system; genitourinary system; liver; retina nuclear layer; and spleen. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human CYP46A1 (cytochrome P450 family 46 subfamily A member 1).