Automated description from the Alliance of Genome Resources
Exhibits cholesterol 24-hydroxylase activity. Involved in cholesterol catabolic process and regulation of long-term synaptic potentiation. Localizes to several cellular components, including the dendrite; endoplasmic reticulum membrane; and postsynapse. Human ortholog(s) of this gene implicated in Alzheimer's disease. Is expressed in several structures, including central nervous system; genitourinary system; liver; retina nuclear layer; and spleen. Orthologous to human CYP46A1 (cytochrome P450 family 46 subfamily A member 1).