Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables pattern recognition receptor activity and peptidoglycan binding activity. Involved in several processes, including nucleotide-binding activity oligomerization domain containing 1 signaling pathway; positive regulation of canonical NF-kappaB signal transduction; and positive regulation of dendritic cell antigen processing and presentation. Acts upstream of or within several processes, including positive regulation of MAPK cascade; positive regulation of cytokine production; and positive regulation of xenophagy. Located in phagocytic vesicle. Is expressed in several structures, including alimentary system; autopod; brain; olfactory epithelium; and urinary system. Human ortholog(s) of this gene implicated in asthma. Orthologous to human NOD1 (nucleotide binding oligomerization domain containing 1).