Automated description from the Alliance of Genome Resources
Exhibits eukaryotic translation initiation factor 2alpha kinase activity and identical protein binding activity. Involved in several processes, including animal organ development; regulation of apoptotic process; and regulation of cellular macromolecule biosynthetic process. Localizes to the endoplasmic reticulum and endoplasmic reticulum membrane. Used to study Wolcott-Rallison syndrome. Human ortholog(s) of this gene implicated in Wolcott-Rallison syndrome and type 1 diabetes mellitus. Is expressed in heart; lens fiber; lens vesicle; and pancreas tip epithelium. Orthologous to human EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3).