Automated description from the Alliance of Genome Resources (Release 3.2)
Exhibits serine-type endopeptidase activity. Involved in epithelial cell morphogenesis involved in placental branching and neural tube closure. Localizes to extracellular region and extrinsic component of plasma membrane. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; pituitary gland; and sensory organ. Used to study Sjogren's syndrome. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 11. Orthologous to human ST14 (ST14 transmembrane serine protease matriptase).