Automated description from the Alliance of Genome Resources (Release 7.0.0)
Predicted to enable several functions, including SMAD binding activity; protein sequestering activity; and signaling receptor binding activity. Involved in several processes, including heart development; negative regulation of ossification; and positive regulation of miRNA transcription. Acts upstream of or within circulatory system development. Predicted to be located in Golgi apparatus; cytosol; and nuclear body. Predicted to be part of heteromeric SMAD protein complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in aortic valve disease 2; craniosynostosis 7; and radioulnar synostosis. Orthologous to human SMAD6 (SMAD family member 6).