Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Minpp1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes multiple inositol polyphosphate phosphatase; an enzyme that removes 3-phosphate from inositol phosphate substrates. It is the only enzyme known to hydrolzye inositol pentakisphosphate and inositol hexakisphosphate. This enzyme also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate; an activity formerly thought to be exclusive to 2,3-BPG synthase/2-phosphatase (BPGM) in the Rapoport-Luebering shunt of the glycolytic pathway.[provided by RefSeq, Sep 2009]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Minpp1:
  • performs the following molecular functions:
    • bisphosphoglycerate 3-phosphatase activity
    • inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity
    • inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity

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Summary text based on GO annotations supported by structural data

• Minpp1 encodes a protein or proteins that contain the following InterPro domains: Histidine acid phosphatase, eukaryotic, Histidine phosphatase superfamily, clade-2, indicating that the gene product:
  • performs the following molecular functions:
    • acid phosphatase activity
    • phosphatase activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Minpp1 indicates that it:
  • performs the following molecular functions:
    • hydrolase activity
  • is located in the following cellular components:
    • endoplasmic reticulum
    • membrane
    • plasma membrane
• Minpp1 has been associated with the Enzyme Commission numbers: 3.1.3.62, 3.1.3.80, which implies that the gene product:
  • performs the following molecular functions:
    • inositol hexakisphosphate 2-phosphatase activity
    • inositol-hexakisphosphate phosphatase activity

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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