Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cds2. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Cds2
  • is located in the following cellular components:
    • endoplasmic reticulum ^[1]

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Summary text based on GO annotations supported by structural data

• Cds2 encodes a protein or proteins that contain the following InterPro domains: Phosphatidate cytidylyltransferase, Phosphatidate cytidylyltransferase, eukaryota, indicating that the gene product:
  • performs the following molecular functions:
    • transferase activity, transferring phosphorus-containing groups
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Cds2 indicates that it:
  • participates in the following biological processes:
    • lipid metabolic process
    • phospholipid biosynthetic process
  • performs the following molecular functions:
    • nucleotidyltransferase activity
    • transferase activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane
    • mitochondrial inner membrane
    • mitochondrion

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References

1. Inglis-Broadgate SL et al. (2005) Isolation and characterization of murine Cds (CDP-diacylglycerol synthase) 1 and 2. Gene, 356:19-31. (PubMed:16023307)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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